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免疫机制在乙型肝炎的发生中具有重要作用,曾试用多种免疫疗法,但迄今无一种有较满意的疗效.抗病毒治疗为最根本的治疗.一、干扰素(IFN):IFN 分为α、β和γ三种类型.IFN-α又可进一步分成16种,由人白细胞或类淋巴细胞经仙台病毒诱生产生的为 IFN-α的混合体,由基因工程生产的重组 DNA 的 IFN-α则为单一的.IFN-β由成纤维细胞产生,与 IFN-α有30%的同源性.IFN-γ是由 T 淋巴细胞产生,其结构和作用机制与前二者不同.(一)IFN-α:类淋巴细胞 IFN-α和重组IFN-α对于抑制 HBV 的增殖复制效果肯定.用IFN-α治疗慢性乙型肝炎,有效率为30～60%.病人用药后 HBV 复制指标(DNA 多聚酶,HBV-DNA和 HBeAg)持续转阴,伴有临床、肝功能的好转,
Immune mechanism plays an important role in the occurrence of Hepatitis B, have tried a variety of immunotherapy, but so far no one has a satisfactory effect.Antiviral therapy is the most fundamental treatment.I, interferon (IFN): IFN Α, β and γ .IFN-α can be further divided into 16 kinds, from human leukocytes or lymphoid cells induced by Sendai virus is a mixture of IFN-α, recombinant DNA produced by genetic engineering IFN-α is a single.IFN-β is produced by fibroblasts and has 30% homology with IFN-α, which is produced by T lymphocytes and has a different structure and mechanism of action than the former two. (A) IFN-α: IFN-α-like lymphocytes and recombinant IFN-α for the inhibition of the proliferation of HBV replication was confirmed with IFN-α treatment of chronic hepatitis B, the effective rate of 30 to 60% of patients treated with HBV replication Indicators (DNA polymerase, HBV-DNA and HBeAg) continued to negative, with clinical, liver function improvement,