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垂体腺甘酸环化酶激活肽(Pituitary Aden ylate Cyclase-Activting Polypeptide,PA CAP)是最近发现的一种新的神经肽,具有强大的舒血管作用.其对血管内皮细胞(EC)作用如何,尚未见报道.已认识到EC功能的破坏,是导致动脉粥样硬化(AS)的关键.我们以离体培养的猪主动脉EC为实验对象,观察PACAP对其产生的影响.实验分四组:①正常对照组:培养基为单纯的无血清M199;②PACAP组:无血清M199中含10-
Pituitary Adenylate Cyclase-Activating Polypeptide (PA CAP) is a newly discovered neuropeptide with potent vasodilatory effect on vascular endothelial cells (EC) See reports.It has been recognized that the destruction of EC function is the key to lead to atherosclerosis (AS) .We in vitro cultured porcine aorta EC as an experimental object to observe the impact of PACAP its impact in four groups: ① normal control group: pure serum-free medium M199; ② PACAP group: serum-free M199 containing 10-