Efficient synthesis of 4(3H)-quinazolinones using a soluble polymeric support

• 出 处: Chinese Chemical Letters
• 发表日期: 2008年05期
• 关键词: polymeric glycol have readily attractive hexane diethyl removed removing advanta

4(3H)-Quinazolinones have been synthesized from poly(ethylene glycol)(PEG)supported aza-Wiuig reaction.2-Dialkylamino- 4(3H)-quinazolinones 6 were synthesized efficiently by reaction of secondary amine with PEG-supported carbodiimides 4,which were obtained from aza-Wittig reaction of PEG-supported iminophosphoranes 3 with isocyanates.

4 (3H) -Quinazolinones have been synthesized from poly (ethylene glycol) (PEG) supported aza-Wiuig reaction.2- Dialkylamino- 4 (3H) -quinazolinones 6 were given efficiently efficiently by reaction of secondary amine with PEG-supported carbodiimides 4, which were obtained from aza-Wittig reaction of PEG-supported iminophosphoranes 3 with isocyanates.