论文部分内容阅读
目的探讨DTI及扩散张量纤维束成像(DTT)诊断星形细胞瘤与脑膜瘤的价值。方法对22例经病理证实的脑肿瘤患者(不同级别星形细胞瘤12例,良性脑膜瘤10例),测量肿瘤实质区与健侧正常脑组织的平均ADC值和FA值,比较测值,并观察两种脑肿瘤对白质纤维束的影响。结果星形细胞瘤及脑膜瘤患者肿瘤实质区FA值均较健侧正常脑组织降低(P均<0.05);星形细胞瘤患者肿瘤实质区ADC值较健侧正常脑组织高(P<0.05),脑膜瘤患者肿瘤实质区ADC值与健侧正常脑组织差异无统计学意义(P>0.05)。星形细胞瘤与脑膜瘤患者比较,肿瘤实质区ADC值、FA值差异有统计学意义(P均<0.05)。在DTT图中,星形细胞瘤多数表现为纤维束部分中断、受压、偏移或变形、移位;脑膜瘤纤维束呈现为稀疏、移位。结论测量肿瘤实质区ADC值和FA值可鉴别脑内和脑外肿瘤如星形细胞瘤与脑膜瘤。DTT可清晰显示脑肿瘤对白质纤维束浸润、破坏和推移,有利于术前制定手术方案。
Objective To investigate the value of DTI and diffusion tensor tractography (DTT) in the diagnosis of astrocytoma and meningioma. Methods Twenty-two pathologically confirmed brain tumor patients (12 different grades of astrocytoma and 10 benign meningioma) were included in this study. The mean ADC value and FA value of the tumor parenchyma and contralateral normal brain tissue were measured. The effects of two kinds of brain tumors on white matter fiber bundles were observed. Results Astrocytomas and meningiomas had lower FA values in the parenchyma than those in the normal tissues (P <0.05). The ADC values in the astrocytomas were higher than those in the normal tissues (P <0.05) ). There was no significant difference in ADC value between the tumor parenchyma and normal brain tissue in meningiomas (P> 0.05). Compared with patients with meningiomas, the ADC values and FA values of tumor in the astrocytomas were significantly different (all P <0.05). In the DTT chart, most of the astrocytomas appear to be interrupted, compressed, displaced or deformed, and displaced in part of the bundle; the meningioma bundles appear sparse and displaced. Conclusion Measurement of ADC values and FA values in the parenchyma of the tumor can identify intracerebral and extracerebral tumors such as astrocytoma and meningioma. DTT can clearly show brain tumor white matter fiber infiltration, destruction and transition, is conducive to the development of surgical options before surgery.