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研究表明支架内再狭窄主要由内膜增生、边缘重构和炎症反应等引起。边缘重构对支架内再狭窄与非支架内再狭窄的主要区别在于剪切力的不同。而剪切力能对内皮细胞的形态和功能产生影响。因此,剪切力、内皮细胞和支架内再狭窄三者关系密切。
Studies have shown that in-stent restenosis is mainly caused by intimal hyperplasia, marginal remodeling and inflammatory response. Marginal reconstruction of intra-stent restenosis and non-stent restenosis in the main difference is the different shear force. Shear force can affect the morphology and function of endothelial cells. Therefore, shear stress, endothelial cells and stent restenosis are closely related.