论文部分内容阅读
目的 研究肺耐药相关蛋白(Lung resistance-related protein,LRP)在乳腺癌组织中的表达,评估其在乳腺癌预后中的作用。方法 采用免疫组织化学方法(Immunohistochemistry,IHC)检测47例手术切除的乳腺癌组织中LRP的表达,并分析其与临床、病理特征的关系及对预后的影响。结果 (1)LRP在乳腺癌组织中的阳性表达率为80.8％(38/47例),其中高表达者22例(51.0％);(2)LRP表达与月经状况、肿瘤大小、腋淋巴结转移、组织分级和激素受体状况均无关(P>0.05);(3)kaplan-Meier生存分析结果表明LRP仅和无病生存期相关(P<0.05),但和总生存期却无关(P>0.05);(4)COX单因素分析显示肿瘤大小和LRP表达与无病生存期明显相关(P<0.05),而肿瘤大小和总生存期也明显相关(P<0.05);在多因素分析中LRP表达仅和无病生存期明显相关,此外腋淋巴结转移与无病生存期和总生存期均明显相关(P<0.05)。结论 LRP在乳腺癌组织中具有较高的表达水平,但与乳腺癌患者预后无关。
Objective To study the expression of lung resistance-related protein (LRP) in breast cancer and evaluate its role in the prognosis of breast cancer. Methods Immunohistochemistry (IHC) was used to detect the expression of LRP in 47 cases of breast cancer undergoing surgical resection. The relationship between the expression of LRP and clinical and pathological features was analyzed. Results (1) The positive expression rate of LRP in breast cancer tissues was 80.8% (38/47 cases), among which 22 cases were high expression (51.0%); (2) LRP expression and menstruation, tumor size, axillary lymph node metastasis There was no correlation between the histological grade and the status of hormone receptors (P>0.05). (3) Kaplan-Meier survival analysis showed that LRP was only associated with disease-free survival (P<0.05), but not with overall survival (P> 0.05); (4) COX univariate analysis showed that tumor size and LRP expression were significantly associated with disease-free survival (P<0.05), and tumor size and overall survival were also significantly associated (P<0.05); in multivariate analysis LRP expression was significantly associated with disease-free survival. In addition, axillary lymph node metastasis was significantly associated with disease-free survival and overall survival (P < 0.05). Conclusion LRP has a higher expression level in breast cancer, but it has nothing to do with the prognosis of breast cancer patients.