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康力龙是治疗再生障碍性贫血(再障)的有效药物之一,近年来国内外已有不少报告应用康力龙治疗再障取得一定疗效,但其引起的肝损害发生率较高。我们发现活血灵-B与康力龙联合治疗再障不仅可以提高疗效,而且能预防康力龙引起的肝损害。本文以活血灵-B和康力龙联合应用,在大鼠中做了实验研究,并对60名再障患者的疗效及肝功变化进行了观察,现报告如下。 1 材料与方法 1.1 动物实验 1.1.1 联合用药对SGPT的影响:实验动物为雄性大鼠,体重约150g,随机分成4组,每组10只。①活血灵-B组:活血灵-B浓缩液0.5ml/只,1次/d,腹腔注射;②康力龙组:康力龙8mg/kg,1次/d,灌胃;③活血灵-B和康力龙(联合用药)组:用药方法
Kang Lilong is one of the effective drugs for the treatment of aplastic anemia (aplastic anemia). In recent years, many reports at home and abroad have reported that Kang Lilong’s treatment of aplastic anemia can achieve certain curative effect, but the incidence of liver damage is high. We found that Huoxingling-B combined with Kangli Long treatment of aplastic anemia not only can improve the curative effect, but also can prevent Kangli Long-induced liver damage. In this paper, Huoxueling-B and the combination of Kang Lilong, rats in an experimental study done, and 60 patients with aplastic anemia efficacy and liver function were observed, are as follows. 1 Materials and Methods 1.1 Animal Experiments 1.1.1 SGPT drug combination effects: experimental animals male rats, weighing about 150g, were randomly divided into 4 groups of 10. ① blood group - B group: Huoxue Ling-B concentrate 0.5ml / only, 1 / d, intraperitoneal injection; ② Kang Lilong group: Kang Lilong 8mg / kg, 1 / (Combination therapy) group: medication method