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目的探讨C反应蛋白(CRP)在慢性阻塞性肺疾病急性加重期(AECOPD)患者治疗前、后的变化和临床意义。方法纳入2008年1月9月住院治疗的80例AECOPD患者,分别测定应用抗生素治疗前后CRP、白细胞计数(WBC)、中性粒细胞百分比(N%)、血沉和体温,并比较这些指标的变化情况。结果 AECOPD患者在感染期CRP总阳性率为100.00%,显著高于治疗前WBC、N%、血沉和体温的阳性率(P<0.05);也显著高于感染控制后(P<0.05)。结论 CRP作为细菌性感染的敏感指标之一,也可作为指导临床及时、正确使用或评价抗生素疗效的一个指标。
Objective To investigate the changes and clinical significance of C-reactive protein (CRP) before and after treatment in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Eighty patients with AECOPD hospitalized in January 2008 were enrolled in this study. CRP, WBC,% of neutrophils (N%), erythrocyte sedimentation rate (ESR) and body temperature were measured before and after antibiotic treatment. The changes of these indexes were compared Happening. Results The positive rate of CRP in patients with AECOPD during infection was 100.00%, which was significantly higher than that before treatment (WBC, N%, ESR and body temperature, P <0.05). Conclusions As a sensitive indicator of bacterial infection, CRP can also be used as an indicator to guide the clinical timely, correct use or evaluation of antibiotic efficacy.