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目的观察微生态制剂培菲康与美沙拉嗪联合用药治疗轻、中度溃疡性结肠炎的疗效及对血清炎症因子的影响。方法将本院收治的轻、中度溃疡性结肠炎患者94例按随机数字表法分为两组(对照组和观察组),每组各47例,对照组给予美沙拉嗪治疗,观察组给予培菲康+美沙拉嗪治疗,比较2组疗效。结果观察组治疗后总体疗效优于对照组,且复发率低,差异有统计学意义(P<0.05);两组治疗后内镜及疾病活动指数评分与治疗前比较均有明显改善(P<0.05),且观察组2指标改善程度优于对照组,其差异有统计学意义(P<0.05);治疗后2组血清炎性因子TN F-a、IL-6、IL-8与治疗前比较均下降,IL-10水平均升高,但观察组各指标改善幅度均显著大于对照组,差异有统计学意义(P<0.05)。结论微生态制剂联合美沙拉嗪治疗轻、中度溃疡性结肠炎可提高疗效,降低复发率,缓解临床症状,值得推广应用。
Objective To observe the curative effect of probiotics combined with mesalazine on mild and moderate ulcerative colitis and its effect on serum inflammatory factors. Methods Ninety-four patients with mild to moderate ulcerative colitis admitted to our hospital were divided into two groups (control group and observation group) by random number table method, 47 in each group. The control group was treated with mesalazine and the observation group Pefikan + mesalazine treatment was given, and the efficacy of the two groups was compared. Results The overall efficacy of the observation group was better than that of the control group after treatment, and the recurrence rate was low, the difference was statistically significant (P <0.05); The endoscopic and disease activity index scores of both groups were significantly improved after treatment (P < 0.05), and the improvement of the index of observation group 2 was better than that of the control group (P <0.05). After treatment, the levels of serum inflammatory cytokines TN Fa, IL-6 and IL-8 (P <0.05). However, the levels of IL-10 in the observation group were significantly higher than those in the control group (P <0.05). Conclusions The combination of probiotics and mesalazine in the treatment of mild to moderate ulcerative colitis can improve the curative effect, reduce the relapse rate and relieve the clinical symptoms, which deserved to be popularized and applied.