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[目的]探讨血清DJ-1蛋白在肺癌、食管癌、乳腺癌及结直肠癌患者的血清浓度及其临床意义。[方法]采用ELISA方法定量检测72例肺癌患者、62例食管癌患者、50例乳腺癌患者、62例结直肠癌患者及64名健康体检者的血清DJ-1浓度。[结果]肺癌组血清DJ-1浓度(M=17.84ng/ml)显著高于其他3组肿瘤及健康体检者(M=4.38ng/ml)(P<0.001)。结直肠癌(M=11.29ng/ml)与食管癌(M=10.59ng/ml)血清DJ-1浓度均高于健康体检者(P=0.016,P=0.076)。乳腺癌血清DJ-1浓度(M=0.00ng/ml)显著低于其他3组肿瘤及健康体检者(P<0.05)。[结论]与正常人相比,肺癌、结直肠癌患者血清DJ-1浓度升高,而乳腺癌患者降低,提示不同器官来源的肿瘤患者血清DJ-1的浓度有差异。
[Objective] To investigate the serum concentration of serum DJ-1 protein in patients with lung cancer, esophageal cancer, breast cancer and colorectal cancer and its clinical significance. [Method] The serum concentration of DJ-1 in 72 patients with lung cancer, 62 patients with esophageal cancer, 50 patients with breast cancer, 62 patients with colorectal cancer and 64 healthy people were measured by ELISA. [Results] The serum concentration of DJ-1 in lung cancer group (M = 17.84ng / ml) was significantly higher than that in other three groups (M = 4.38ng / ml) (P <0.001). The serum concentrations of DJ-1 in colorectal cancer (M = 11.29ng / ml) and esophageal cancer (M = 10.59ng / ml) were higher than those in healthy subjects (P = 0.016, P = 0.076). The serum concentration of DJ-1 in breast cancer (M = 0.00ng / ml) was significantly lower than those in the other three groups (P <0.05). [Conclusions] Compared with normal people, the concentration of serum DJ-1 in patients with lung cancer and colorectal cancer is increased, while it is lower in patients with breast cancer, suggesting that the concentration of serum DJ-1 in cancer patients with different organ origins is different.