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目的:正确评价国产重组人生长激素(r-hGH)对促进生长激素缺乏症(GHD)儿童身高增长作用的疗效和安全性,观察相关血清生化指标的变化.方法:选择GHD患儿9例,给予国产r－hGH0.1IU/kg?d,疗程6个月.结果:治疗后生长速度由(2.66±1.07)cm/年增至(12.62±4.32)cm/年(疗程3个月时),(12.53±3.86)cm/年(疗程6个月时)(P＜0.01);完全性GHD疗程优于部分性GHD.结论:国产r－hGH治疗GHD近期疗效肯定,而且安全可靠.“,”objective:To evaluate the therapeutic effect of China-made recombinant human growth horm-one(r-hGH) on growth hormone deficiency (GHD) in chlidren and to investigate the changes in various serum biochemical parameters. Methods:Nine children with GHD were given China-made r-hGH of 0. 1IU/kg.d for 6 months. Results:After the first 3 and 6 months of therapy the grewth veocities were significantly increased [(12.62 ±4.34) and (12.52 ±3.86)]cm/year respectively compared with the pretreatment value [(2.66 ±1 .07)cm/year, P<0.01].Conclusion:The growth stimulating effect and safety are confirmed in use of the China-made r-hGH in the treatment of GHD children for 6 months.