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目的:探讨甲状旁腺功能减退症(简称甲旁减)患者维生素D代谢障碍的原因.方法:我们采用放射免疫法、竞争蛋白结合法、放射受体法测定了23例甲旁减及20例健康成人血甲状旁腺素(PTH)、25(OH)D3、1.25(OH)2D3水平.结果:甲旁减病人血PTH明显低于正常人,甲旁减病人组在口服维D2情况下,血25(OH)D3明显高于正常组,而1.25(OH)2D3低于正常组.结论:甲旁减病人因缺少生成1.25(OH)2D3所必需的促激素PTH,肾脏即使在服用维生素D2所致高水平的25(OH)D3状态下,也不能生成足量的、适应体内需要的1.25(OH)2D3,故临床治疗本病应首选1.25(OH)2D3制剂.“,”objective: To study the cause of vitamine D metabolism disorder in patients with hypoparatbyroidism. Methods:Plasma PTH, 25OHD3 and 1.25(OH)2D3 were measured by redioimmunoassay (RIA) in 23 paticnts with hypoparathyroidism and 20normal subjects. Results:The results showed that the levels of plasma PTH were lower in patients group than those in the control group with significant difference (P