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高剂量大容积５－Ｆｕ腹腔给药后２４０分钟内腹腔液浓度是股静脉血浓度的２８８倍，门静脉血浓度是股静脉血浓度的１３．８倍，肝静脉血浓度是股静脉血浓度的３．７倍，组织中肝浓度最高，胃、结肠次之，肺、肾最低。经腹腔化疗后的腹腔荷人结肠癌移植瘤裸鼠对照组全部产生腹腔移植瘤，５－Ｆｕ１０和２０ｍｇ／ｋｇ组均有２／５产生腹腔移植瘤，３０ｍｇ／ｋｇ组无腹腔移植瘤产生。结果表明高剂量大容积５－Ｆｕ腹腔化疗有利于胃肠恶性肿瘤术后腹腔复发和肝转移的防治。
The intraperitoneal concentration was 288-fold higher than that of the femoral vein at 240 minutes after intraperitoneal administration of high-dose, large-volume, 5-Fu intraperitoneal injection. The portal vein blood concentration was 13.8 times that of the femoral vein and the hepatic vein concentration was the femoral vein blood concentration 3.7 times, the highest concentration of liver tissue, stomach, colon followed, lung, kidney lowest. The transplanted human colon xenografts in abdominal cavity after intraperitoneal chemotherapy all produced abdominal transplanted tumors in the control group, with 2/5 in the 5-Fu10 and 20 mg / kg groups producing the transplanted abdominal tumor, while the 30 mg / kg group did not produce the abdominal transplanted tumor. The results showed that high-dose, large-volume 5-Fu intraperitoneal chemotherapy is beneficial to the prevention and treatment of postoperative abdominal recurrence and liver metastasis of gastrointestinal malignant tumor.