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The electrochemical behavior of the degradation product of cefdinir(CDR) was studied in a 0.05 mol/L NaOH solution by means of linear sweep voltammetry(LSV) and cyclic voltammetry(CV). The results indicate that the C=N bond in the oxime group was reduced. Moreover, a saturated adsorption amount of 1.32×10-10 mol/cm2 at Hg electrode was obtained. The adsorption coefficient β was 1.56×105 L/mol. Gibbs standard energy of adsorption △G0 at 25 °C was -29.63 kJ/mol and the number of electrons transferred n was 2. A method for the determination of CDR was proposed by differential pulse voltammetry(DPV). The reduction peak currents of the CDR’s degradation product were found to be linear in a concentration range of 4.0×10-7―4.0×10-6 mol/L and that of 4.0×10-8―4.0×10-7 mol/L, respectively. The detection limit was found to be 3.0×10-8 mol/L under the optimized conditions. The applicability of this approach was illustrated by the determination of CDR in capsules. In addition, the mechanism about the degradation of CDR in 0.2 mol/L NaOH was discussed by UV spectrophotometry.
The electrochemical behavior of the degradation product of cefdinir (CDR) was studied in a 0.05 mol / L NaOH solution by means of linear sweep voltammetry (LSV) and cyclic voltammetry (CV). The results indicate that the C = N bond in the oxime The adsorption coefficient β was 1.56 × 105 L / mol. Gibbs standard energy of adsorption △ G0 at 25 ° C was - 29.63 kJ / mol and the number of electrons transferred n was 2. A method for the determination of CDR was proposed by differential pulse voltammetry (DPV). The reduction peak currents of the CDR’s degradation product were found to be linear in a concentration range of 4.0 × 10 -7 -4.0 × 10 -6 mol / L and that of 4.0 × 10 -8 -4.0 × 10 -7 mol / L, respectively. The detection limit was found to be 3.0 × 10 -8 mol / L under the optimized conditions. The applicability of this approach was illustrated by the determination of CDR in capsules. In addition, the m echanism about the degradation of CDR in 0.2 mol / L NaOH was discussed by UV spectrophotometry.