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动物实验显示,抗肿瘤药物顺铂对耳蜗有毒性作用,但对前庭的感觉细胞则无作用。实验将28只成龄豚鼠分成6组,1、2组各5只,3、4组各6只,静注顺铂(12.5mg/kg)后分别于1、2、3、4天麻醉下断头,取颞骨进行耳蜗的组织形态学观察。第5组3只顺铂剂量减为8mg/kg,以作对照,于注药后5天断头处死,第6组3只不注顺铂为对照组。结果
Animal experiments show that anti-tumor drug cisplatin toxic effect on the cochlea, but the vestibular sensory cells have no effect. 28 adult guinea pigs were divided into 6 groups, 5 in group 1, 2 in group 3 and 6 in group 3, respectively. After intravenous cisplatin (12.5 mg / kg), anesthesia was performed on days 1, 2, The decapitation and the temporal bone were observed for histomorphology. In the fifth group, the dose of three cisplatin was reduced to 8mg / kg as the control, which was decapitated 5 days after the injection, and the third group was not injected cisplatin as the control group. result