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胃食管返流(GOR)与哮喘经常同时存在。作者应用胃镜检查研究哮喘患者的食管粘膜损伤的发病情况。作者随机选择了186例诊断为哮喘的门诊患者。内镜检查时,将粘膜肉眼观察分为四级:Ⅰ级为正常,Ⅱ～Ⅳ为具有不同程度的食管炎。组织学的检查仅判断有无Barrett食管。实验研究中对LOS进行了测压,并在患者平静呼吸状态下,统计了有无食管裂孔疝。研究结果发现:1.食管粘膜糜烂或溃疡或两者共存者占哮喘患者的39.3％,其中Ⅱ级者占25.8％,Ⅲ级者占8.1％,Ⅳ级者占5.4％。另外尚有24例(12.9％)患者有Barrett食管,其中18例伴食管炎,6例不伴有食管炎。总之,42.5％的哮喘患者患有食管炎或Barrett食管或两者兼有。食管下括约肌(LOS)压力,吸烟饮酒情况、年龄、有无使用支气管扩张剂与食
Gastroesophageal reflux (GOR) and asthma are often present at the same time. The authors applied gastroscopy to study the incidence of esophageal mucosal injury in asthmatic patients. The authors randomly selected 186 outpatients diagnosed with asthma. Endoscopy, the mucosal macroscopic observation is divided into four levels: Ⅰ grade is normal, Ⅱ ~ Ⅳ have different degrees of esophagitis. Histological examination only to determine the presence of Barrett’s esophagus. LOS in the experimental study of manometry, and in patients with calm breathing, statistics with or without hiatal hernia. The results showed that: 1. Esophageal mucosal erosion or ulcer or the coexistence of the two accounted for 39.3% of patients with asthma, of which 25.8% of grade Ⅱ, Ⅲ grade accounted for 8.1%, Ⅳ grade accounted for 5.4%. In addition, 24 (12.9%) patients had Barrett’s esophagus, 18 with esophagitis and 6 without esophagitis. In summary, 42.5% of asthmatics suffer from esophagitis or Barrett’s esophagus or both. Lower esophageal sphincter (LOS) pressure, smoking and drinking, age, presence or absence of bronchodilators and food