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智能发育不全(Mental retardation,MR)在人群中的发生率约为1-3％,是严重危害小儿健康的一类疾病。本病病因复杂,先天性患者可能是由于在宫内发育过程中受体内外不良因素影响所致,也可以是遗传因素引起。在遗传性智能发育不全中,可是单基因病、多基因病或者染色体病。为探讨染色体畸变在智能发育不全中的作用,自1989年以来,作者对220例智能发育不全患儿进行了细胞遗传学研究,现将结果报告于后。 1 材料和方法 1.1 对象 本组220例为本市计划生育病残鉴定中
Mental retardation (MR) incidence in the population is about 1-3%, which is a type of disease that seriously affects the health of children. The etiology of this disease is complex, congenital patients may be due to intrauterine development in vivo caused by adverse factors inside and outside factors can also be caused by genetic factors. In hereditary hypoplasia, but single gene disease, polygenic disease or chromosomal disease. To investigate the role of chromosomal aberrations in the development of mental retardation, since 1989, the authors conducted a cytogenetic study of 220 children with intellectual underdevelopment, and the results are reported hereafter. 1 Materials and Methods 1.1 Object This group of 220 cases of the city’s family planning and identification of disabled