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Objective: To assess the antinociceptive and anti-inflammatory properties of the aqueous extract of Armadillidium vulgare(AV). Methods: The antinociceptive effect of AV(400, 600 and 800 mg/kg) was investigated in mice using the acetic acid-induced writhing, formalin-induced nociceptive, and hot plate tests. Phlogogen-induced paw edema using carrageenan, dextran, or compound 48/80 as phlogogen was used as inflammatory models to evaluate AV’s anti-inflammatory effect. Additionally, the bioactive substances glucosamine(GLc N) and taurine in AV were determined using high-performance liquid chromatography. Results: Oral treatment of the mice with AV(600 and 800 mg/kg) significantly reduced the number of writhes in the acetic acid-induced writhing test(P<0.01) but not the hot plate test(P>0.05). All doses tested significantly inhibited paw-withdrawal during the second phase of the formalin-induced nociceptive model(P<0.01). AV demonstrated a strong anti-inflammatory effect in all those inflammatory models(P<0.05). Conclusions: AV has antinociceptive and anti-inflammatory effects, providing scientific evidence of the efficacy of its traditional use in pain treatment. Furthermore, GLc N and taurine contribute, at least in part, to the anti-inflammatory activity of AV.
Methods: The antinociceptive effect of AV (400, 600 and 800 mg / kg) was investigated in mice using the acetic acid-induced writhing , formalin-induced nociceptive, and hot plate tests. Phlogogen-induced paw edema using carrageenan, dextran, or compound 48/80 as phlogogen was used as inflammatory models to evaluate AV’s anti-inflammatory effect. Additionally, the bioactive substances glucosamine (GLc N ) and taurine in AV were determined using high-performance liquid chromatography. Results: Oral treatment of the mice with AV (600 and 800 mg / kg) significantly reduced the number of writhes in the acetic acid- induced writhing test (P <0.01) but not the hot plate test (P> 0.05). All reagents tested significantly inhibited paw-withdrawal during the second phase of the formalin-induced nociceptive model (P <0.01). AV demonstrated a strong anti-inflammatory effect in all those infla In addition, GLc N and taurine contribute, at least in part, to the anti-inflammatory drugs, inflammatory activity of AV.