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目的探究宫腔粘连患者宫内膜组织中胰岛素样生长因子-Ⅰ(IGF-Ⅰ)和转化生长因子β1(TGF-β1)及其受体表达的临床意义。方法择取南方医科大学附属深圳市妇幼保健院2012年6月-2014年9月收治的56例接受宫腔镜手术的宫腔粘连者为实验组,依据宫腔粘连程度,将其划分为A组(轻度粘连)、B组(中度粘连)、C组(重度粘连)3组,并另择取22例非宫腔粘连患者为对照组,观察各组IGF-Ⅰ及TGF-β1及其受体表达变化情况。结果实验组IGF-Ⅰ阳性细胞百分率(12.75±4.50)/(25.88±6.52)/(48.36±7.84)vs(7.32±2.51)、IGF-ⅠR阳性细胞百分率(10.35±3.47)/(20.05±3.77)/(44.97±3.34)vs(6.36±2.77)明显高于对照组,且TGF-β1阳性细胞百分率(19.32±6.59)/(27.64±7.18)/(51.48±8.59)vs(8.60±3.36)、TGF-β1R阳性细胞百分率(14.06±4.78)/(19.10±5.18)/(40.48±5.14)vs(6.04±1.09)亦高于对照组,差异具有显著统计学意义(P<0.05)。结论 IGF-和TGF-β1在宫腔粘连的发病中具有重要作用。
Objective To investigate the clinical significance of the expression of insulin-like growth factor-Ⅰ (IGF-Ⅰ), transforming growth factor-β1 (TGF-β1) and their receptors in endometrial tissue of patients with intrauterine adhesions. Methods 56 cases of uterine cavity adhesions undergoing hysteroscopic surgery admitted to Shenzhen Maternal and Child Health Hospital Affiliated to Southern Medical University from June 2012 to September 2014 were selected as the experimental group. According to the intrauterine adhesions, they were divided into A Group B (mild adhesion), Group C (severe adhesion), and another 22 patients with non-uterine adhesions were selected as the control group. The levels of IGF-Ⅰ and TGF-β1 Its receptor expression changes. Results The percentage of IGF-Ⅰ positive cells in experimental group was (12.75 ± 4.50) / (25.88 ± 6.52) / (48.36 ± 7.84) vs (7.32 ± 2.51), the percentage of IGF-ⅠR positive cells was (10.35 ± 3.47) / (20.05 ± 3.77) /(44.97 ± 3.34)vs(6.36 ± 2.77) was significantly higher than that of the control group, and the percentage of TGF-β1 positive cells (19.32 ± 6.59) / (27.64 ± 7.18) / (51.48 ± 8.59) vs (8.60 ± 3.36) (14.06 ± 4.78) / (19.10 ± 5.18) / (40.48 ± 5.14) vs (6.04 ± 1.09) were also higher than those in the control group, the difference was statistically significant (P <0.05). Conclusion IGF- and TGF-β1 play an important role in the pathogenesis of intrauterine adhesions.