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目的:探讨胰腺癌缺失基因(DPC4)在急性白血病(AL)中的表达情况及其与临床的关系。方法:采用RT-PCR方法检测32例AL患者骨髓细胞及9例正常人骨髓细胞DPC4表达情况。结果:AL患者骨髓细胞DPC4基因表达阳性率为75.00%,正常人骨髓细胞DPC4基因表达阳性率为77.78%,二者比较差异无统计学意义。结论:DPC4基因的表达缺失未参与AL的发病。
Objective: To investigate the expression of pancreatic cancer deletion gene (DPC4) in acute leukemia (AL) and its clinical significance. Methods: The expression of DPC4 was detected by RT-PCR in bone marrow cells of 32 AL patients and in 9 normal human bone marrow cells. Results: The positive rate of DPC4 gene in bone marrow cells was 75.00% in AL patients and 77.78% in normal human bone marrow cells. There was no significant difference between the two groups. Conclusion: The loss of DPC4 gene expression is not involved in the pathogenesis of AL.