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目的分析研究莫西沙星超短程治疗初治菌阳肺结核的临床效果及运用价值。方法抽取2014年1月—2015年11月濮阳市第五人民医院收治的96例初治菌阳肺结核患者,随机分为两组,各48例。对照组采用常规2HRZE/4HR化疗方案,观察组采用2HRZEM/2HRM超短程治疗方案。统计两组痰结核菌转阴率、病灶吸收有效率及不良反应发生率,并对比两组治疗前后生活质量评分。结果观察组治疗2个月痰结核菌转阴率87.50%与疗程结束时转阴率95.83%均高于对照组70.83%与83.33%,差异有统计学意义(P<0.05);观察组病灶吸收有效率100.00%高于对照组87.50%,差异有统计学意义(P<0.05);观察组不良反应发生率为8.33%,与对照组6.25%相比,差异无统计学意义(P>0.05);治疗前,两组生活质量评分比较,差异无统计学意义(P>0.05),经治疗,观察组生活质量评分显著高于对照组(P<0.05)。结论莫西沙星用于初治菌阳肺结核超短程治疗,可有效提高患者痰结核菌转阴率、促进病灶吸收,具有一定安全性,且有利于改善患者生活质量。
Objective To study the clinical effect and the value of using moxifloxacin in the treatment of newly diagnosed bacillary positive pulmonary tuberculosis. Methods Totally 96 untreated bacillary positive pulmonary tuberculosis patients admitted to the Fifth People’s Hospital of Puyang City from January 2014 to November 2015 were randomly divided into two groups of 48 cases each. Control group using conventional 2HRZE / 4HR chemotherapy regimen, the observation group using 2HRZEM / 2HRM ultrashort regimen. The negative rate of TB, the effective rate of lesion absorption and the incidence of adverse reactions were compared between the two groups, and the quality of life scores of two groups were compared before and after treatment. Results In the observation group, 87.50% of sputum bacterium was found to be negative in the observation group and 95.83% in the end of the treatment period, which were significantly higher than those in the control group (70.83% vs 83.33%, P <0.05) The effective rate was 100.00% higher than that of the control group (87.50%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 8.33%, which was not significantly different from that of the control group (6.25% Before treatment, there was no significant difference in quality of life between the two groups (P> 0.05). After treatment, the quality of life in the observation group was significantly higher than that in the control group (P <0.05). Conclusion Moxifloxacin for the initial treatment of bacillary tuberculosis ultra-short-term treatment can effectively improve the patient’s sputum TB negative rate and promote the absorption of the lesion, with a certain safety, and help to improve the quality of life of patients.