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本文报告侧脑室微量注入纳洛酮,对家兔肠系膜上动脉闭塞性(SMAO)休克及休克过程中交感神经电活动的影响。通过40例家兔实验证明,纳洛酮组较对照组松夹后交感神经放电活动增强且持续时间大大延长。说明交感神经中枢的机能活动参与了纳洛酮的抗休克作用。但交感神经电活动减弱后纳洛酮组还能维持较高的血压水平并维持较长的时间,说明动物血压的维持除交感神经紧张性调节外,还有其它机制的参与。纳洛酮组动物存活时间大大延长的事实充分表明纳洛酮确有对抗SMAO休克的作用。因此纳洛酮可能具有临床应用价值。
This article reports the effects of microinjection of naloxone into the lateral ventricle on the sympathetic electrical activity in rabbit superior mesenteric artery occlusion (SMAO) shock and shock. The experiment of 40 rabbits proved that the activity of sympathetic nerve discharge in naloxone group was significantly prolonged compared with the control group. It shows that the functional activity of the sympathetic nerve center is involved in the anti-shock effect of naloxone. However, after the sympathetic nerve activity decreased, the naloxone group could maintain a higher blood pressure level and maintain a longer time, indicating that in addition to sympathetic nervous regulation, there are other mechanisms involved in the maintenance of blood pressure in the animal. The fact that the naloxone group significantly prolonged the survival of animals fully demonstrated that naloxone does have an effect against SMAO shock. Therefore, naloxone may have clinical value.