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目的探讨双侧髂内动脉加门静脉置泵化学治疗（三泵化疗）预防直肠癌根治术后局部复发和肝脏转移的价值。方法回顾性总结直肠癌根治术１４６例患者采用三泵化疗（Ⅰ组）４４例，单侧髂内动脉加门静脉置泵化疗（Ⅱ组）５０例，全身化疗（Ⅲ组）５２例，均行５氟脲嘧啶加丝裂霉素Ｃ化疗方案。结果ＤｕｋｅｓＣ期患者：Ⅰ组３年生存率、局部复发率、肝转移率分别为８２１％、１０７％、７１％，Ⅲ组为４３３％、５０％和３６７％，两组分别相比差异均有显著意义（Ｐ＜００１）。Ⅱ组局部复发率（４０６％）与Ⅰ组（１０７％）相比差异有显著意义（Ｐ＜００１）。结论三泵化疗效果优于全身化疗，双侧髂内动脉置泵化疗优于单侧髂内动脉置泵化疗。
Objective To investigate the value of bilateral internal iliac arteries plus portal vein chemotherapy (triple pump chemotherapy) in the prevention of local recurrence and liver metastasis after radical resection of rectal cancer. Methods A retrospective review of 146 patients undergoing radical resection of rectal cancer using tri-pump chemotherapy (Group I) in 44 patients, unilateral internal iliac arteries plus portal vein chemotherapy (Group II) in 50 patients, and systemic chemotherapy in Group III (52 patients) were performed. 5-fluorouracil plus mitomycin C chemotherapy regimen. Results Patients with Dukes C stage disease: The 3-year survival rate, local recurrence rate, and hepatic metastasis rate in group I were 82.1%, 10.7%, and 7.1%, respectively, and those in group III were 43.4%, 50%, and 36.7%. %, the difference between the two groups were significant (P <0 01). The local recurrence rate in group II (40.6%) was significantly different from that in group I (10.7%) (P < 0.01). Conclusion Tri-pump chemotherapy is superior to systemic chemotherapy, and bilateral internal iliac artery pumping is superior to unilateral internal iliac artery pumping chemotherapy.