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在人类中,根据胰岛组织学,针对胰岛细胞的细胞介导免疫和胰岛细胞抗体的检出等证据,说明胰岛素依赖型糖尿病(insulin-dependent diabetes mellitus,IDDM)可能是一种自身免疫性疾病,从而也开创了免疫抑制剂治疗糖尿病的新途径。环孢菌素(cyclosporine,Cy)作为免疫抑制剂,单独或与激素联合用于抑制移植排斥优于硫唑嘌呤。作者企图通过Cy的免疫抑制作用,诱导IDDM的缓解期而达到其治疗目的。 41例病人均确诊为IDDM,空腹和胰离血糖索激惹后的血清免疫C肽处于正常空腹范围内,而胰岛素治疗少于12个月。男24、女17例。年龄8～49岁。用放射免疫、比色及免疫荧光法分别测定血浆C肽、
In humans, insulin-dependent diabetes mellitus (IDDM) may be an autoimmune disease based on evidence of pancreatic islet histology, cell-mediated immunity against islet cells, and detection of islet cell antibodies, Thus creating a new way for immunosuppressants to treat diabetes. Cyclosporine (Cy), as an immunosuppressive agent, is used alone or in combination with hormones to inhibit graft rejection over azathioprine. The authors attempt to achieve their therapeutic goals through the immunosuppressive effects of Cy and induction of remission of IDDM. Forty-one patients were diagnosed with IDDM. Serum immunized C-peptide in fasting and pancreatic blood from glucocorticoid-induced challenge was in the normal fasting range, while insulin therapy was less than 12 months. Male 24, female 17 cases. Age 8 to 49 years old. Plasma radio-immunity, colorimetric and immunofluorescence were used to detect plasma C-peptide,