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1例75岁女性患者,因带状疱疹给予膦甲酸钠3 g、1次/d静脉滴注,合并应用甲钴胺、维生素B1和新癀片、阿昔洛韦软膏。第4天,患者四肢及面部出现水肿,伴恶心、食欲不振、皮肤瘙痒。第10天,除阿昔洛韦软膏外,上述药物均停用。第12天实验室检查:血清肌酐142μmol/L,尿素氮8.6 mmol/L;尿比重1.010。考虑为急性肾衰竭、急性间质性肾炎。限制液体入量,给予低盐、低脂、优质蛋白饮食。5 d后患者水肿消退,瘙痒消失。实验室复查:血清肌酐86μmol/L,尿素氮7.4 mmol/L,磷0.9 mmol/L。
A 75-year-old woman with herpes zoster was given an intravenous infusion of 3 g of foscarnet 1 time per day in combination with mecobalamin, vitamin B1 and nephew tablets, and acyclovir ointment. The fourth day, patients with extremities and facial edema, with nausea, loss of appetite, itchy skin. The 10th day, in addition to acyclovir ointment, the above drugs are disabled. Day 12 laboratory tests: serum creatinine 142μmol / L, urea nitrogen 8.6 mmol / L; urine specific gravity 1.010. Considered acute renal failure, acute interstitial nephritis. Limit liquid intake, given low salt, low fat, high-quality protein diet. After 5 days, the patient’s edema subsided and the itching disappeared. Laboratory review: serum creatinine 86μmol / L, urea nitrogen 7.4 mmol / L, phosphorus 0.9 mmol / L.