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目的观察趋化性细胞因子受体CXCR4在结直肠癌中的表达和微血管密度MVD与肿瘤转移的关系。方法用免疫组化的方法检测56例结直肠癌、10例癌旁组织中CXCR4的表达,用血管因子标记血管内皮细胞计数微血管密度,分析CXCR4与微血管密度及其肿瘤转移的关系。结果结直肠癌组织CXCR4的表达高于癌旁组织,与结直肠癌淋巴结转移、临床分期和微血管密度密切相关。结论CXCR4在结直肠癌中表达明显升高,可能与结直肠癌血管生成和转移有关。
Objective To observe the expression of chemokine receptor CXCR4 in colorectal cancer and the relationship between MVD and tumor metastasis. Methods The expression of CXCR4 was detected by immunohistochemistry in 56 cases of colorectal cancer and 10 cases of paracancerous tissues. The microvessel density (MVD) of vascular endothelial cells was counted by vascular factor. The relationship between CXCR4 and microvessel density and tumor metastasis was analyzed. Results The expression of CXCR4 in colorectal cancer tissues was higher than that in paracancerous tissues, which was closely related to lymph node metastasis, clinical stage and microvessel density in colorectal cancer. Conclusion The expression of CXCR4 is significantly increased in colorectal cancer, which may be related to the angiogenesis and metastasis of colorectal cancer.