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目的探讨血清胱抑素C(CysC)在肾脏疾病诊断中的临床价值。方法将354例肾病患者按肾脏损伤程度分为4组,检测血清BUN、Scr、UA和CysC并进行对比分析,同时比较BUN、Scr、UA、CysC之间的相关性及敏感性。试验设104例健康对照。结果肾功能基本正常组与健康对照组比较CysC差异有统计学意义(P<0.05);随着肾脏损伤程度的加重,BUN、Scr、UA、CysC均显著升高,组间差异有统计学意义(P<0.05);4指标异常率与肾损伤程度呈正相关,其中CysCr=0.979。肾功能轻度异常组Scr异常率最低(37.2%),肾功能重度异常组UA异常率最低(72.9%)。结论 CysC是肾功能早期损害的灵敏诊断指标,CysC和BUN可用于评价肾脏疾病的进展和判断预后,Scr在轻度肾损伤时不敏感,UA不能单独作为评价肾脏疾病的进展和判断预后的指标。
Objective To investigate the clinical value of serum cystatin C (CysC) in the diagnosis of renal disease. Methods 354 patients with nephropathy were divided into 4 groups according to the degree of renal injury. Serum BUN, Scr, UA and CysC were detected and compared, and the correlation and sensitivity between BUN, Scr, UA and CysC were compared. Test set 104 cases of healthy controls. Results There was a significant difference in CysC between normal control group and healthy control group (P <0.05). The levels of BUN, Scr, UA and CysC were significantly increased with the severity of renal injury, and the difference was statistically significant (P <0.05). There was a positive correlation between the abnormal rate of 4 indexes and the degree of renal injury, among which CysCr was 0.979. The abnormal rate of Scr was the lowest (37.2%) in patients with mild renal dysfunction and the lowest (72.9%) was abnormal in patients with severe renal dysfunction. Conclusions CysC is a sensitive diagnostic indicator of early renal damage. CysC and BUN can be used to evaluate the progression of renal disease and prognosis. Scr is not sensitive to mild renal injury. UA can not be used alone as an index to evaluate the progression of renal disease and prognosis .