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由于Down氏综合症患者的不良卫生习惯和异常行为特性,其感染乙型肝炎和成为活动性携带者的机会大为增加,促使病毒在聚集人群内传播。所以提倡对痴呆症病院的人员进行乙型肝炎免疫预防接种。 用低剂量乙肝疫苗经皮下接种的报导,认为对痴呆症患者以此法进行免疫是可行的。首先,注射两次疫苗,每次2μgHBsAg,间隔一个月。注射第二针一个月后采血测定免疫反应,结果与早期研究的报道相同。然后进行两次加强免疫(第5和第10个月,每次2 μgHBsAg)。 对92名痴呆症患者、28名工作人员也以同法免疫。所有受试者在实验初期均为HBsAg和抗-HBs阴性;在实验结束时,抗-
Due to unhealthy habits and abnormal behavior in Down’s syndrome patients, their chance of becoming infected with Hepatitis B and becoming active carriers is greatly increased, prompting the spread of the virus within the aggresome population. So to promote dementia hospital personnel hepatitis B immunization vaccination. Subcutaneous vaccination with low-dose hepatitis B vaccine reported that it is feasible to immunize patients with dementia by this method. First, vaccinate twice with 2 μg HBsAg at one month intervals. One month after the injection of the second needle, the blood was collected and the immune response was measured. The results were the same as those reported in earlier studies. Followed by two booster immunizations (2 μg HBsAg at 5 and 10 months). In 92 dementia patients, 28 staff also received immunization. All subjects were negative for HBsAg and anti-HBs at the beginning of the experiment; at the end of the experiment, anti-