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在新药研究中,化学、药理学、药剂学和临床学研究都是不可缺少的工作。这些工作只有彼此配合,密切联系,才能提高研究效果。在研究过程中,各学科必须按照合理的程序进行工作,才能更好地发挥各自的作用。六十年代美国国立癌症研究所的科学家总结肿瘤化疗药物研究经验,首次制定了新药研究的线型规划(linear array),对样品来源、筛选程序、药理、毒理和临床试验提出了基本方案。七十年代西德保林格公司(Boehringer Ingelheim)使用由线型规划发展起来的网络计划(network plan)来控制新药研究,使各阶段任务明确,各学科协作井然。意大利克罗埃帕制药公司(Farmitalia Calro Erba)在研究抗癌抗生素中的程序也体现了科学管理的优越性。近二十年的经验表明,药物研究活动必须根据各阶段工作重点,列出计划程序。而在不同的计划程序中,线型规划可认
In new drug research, chemistry, pharmacology, pharmacy and clinical research are indispensable work. Only by working together and in close connection with each other can we improve the research results. In the course of the study, all disciplines must work according to reasonable procedures in order to better play their respective roles. In the 1960s, scientists from the National Cancer Institute summarized the research on cancer chemotherapeutic drugs. For the first time, they formulated a linear array of new drug research and put forward basic plans for source of samples, screening procedures, pharmacology, toxicology and clinical trials. In the seventies Boehringer Ingelheim used a network plan developed by a linear program to control the research of new drugs, making the tasks of all phases clear and well coordinated across disciplines. Farmitalia Calro Erba’s program of studying anti-cancer antibiotics also reflects the superiority of scientific management. Nearly two decades of experience have shown that drug research activities must outline planning processes based on the priorities of each phase. In different planning programs, linear programming can be recognized