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目的了解宁波地区原发性与获得性耐多药患者年龄分布特征及临床耐药情况,为耐多药的防治提供科学依据。方法将宁波地区2008年-2012年进行耐药监测期间收集的耐多药患者资料进行分析(原发性耐多药196例,获得性耐多药109例)。将患者年龄分为4组,其中<20岁组17例,20~岁组144例,40~岁组106例,60~岁组38例,分别分析其耐药情况。结果原发性耐多药和获得性耐多药患者中,均以20~岁组的比例最高,经统计学处理,原发性耐多药和获得性耐多药在不同年龄组的分布差异有统计学意义(Fisher确切概率法,P=0.043),耐多药种类(HR、HRE、HRS、HRSE)在原发性耐多药的20~岁组、40~岁组和60~岁组间比较,差异有统计学意义(χ2=34.28,P<0.05);获得性耐多药种类在不同年龄组中比较,差异无统计学意义(Fisher确切概率法,P>0.05)。结论原发性和获得性耐多药以年轻患者为主,耐多药情况较为严重,应加强结核病患者的诊治,减少耐多药现象。
Objective To understand the age distribution characteristics and clinical drug resistance of patients with primary and acquired multidrug-resistant in Ningbo and to provide a scientific basis for the prevention and treatment of multidrug-resistant multi-drug. Methods The data of MDR-resistant patients collected during drug resistance surveillance from 2008 to 2012 in Ningbo were analyzed (196 cases of primary MDR and 109 cases of acquired multi-MDR). Patients were divided into 4 groups, including 17 cases in 20 years old, 144 cases in 20 ~ group, 106 cases in 40 ~ group and 38 cases in 60 ~ Results Among the patients with primary multidrug-resistant and multidrug-resistant MDR, the highest proportion was in the 20-year-old group, and the difference was statistically significant in the distribution of the primary multidrug-resistant and acquired multi-drug-resistant in different age groups (Fisher exact test, P = 0.043), multidrug resistance (HR, HRE, HRS, HRSE) in the primary MDR 20 to 40 years old group and 60 to 60 years old group The difference was statistically significant (χ2 = 34.28, P <0.05). There was no significant difference in acquired multidrug-resistant species in different age groups (Fisher exact test, P> 0.05). Conclusions Primary and acquired MDR are mainly young patients, and MDR is more serious. Diagnosis and treatment of TB patients should be strengthened to reduce MDR.