Nonalcoholic fatty liver disease:A comprehensive review of a growing epidemic

• 作 者: Kareem Hassan Varun Bhalla Mohammed Ezz El Regal H Hesham A-Kader
• 机 构: Division of Gastroenterology,Hepatology and Nutrition,Department of Pediatrics,The University of Ari
• 出 处: World Journal of Gastroenterology
• 发表日期: 2014年34期
• 关键词: epidemic NASH obesity subsequent pathogenesis have elucidate quickly PPAR alcoho

Nonalcoholic fatty liver disease(NAFLD)is quickly becoming one of the most prominent causes of liver disease worldwide.The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it.Current efforts to elucidate the mechanism and causes of the disease have answered some questions,but much remains unknown about NAFLD.The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease,as well as the current and future diagnostic,preventative,and therapeutic options available to clinicians for the management of NAFLD.

Nonalcoholic fatty liver disease (NAFLD) is quickly becoming one of the most prominent causes of liver disease worldwide. The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it. Current efforts to elucidate the mechanism and causes of the disease have answered some questions, but much remains unknown about NAFLD. The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease, as well as the current and future diagnostic, preventative, and therapeutic options available to clinicians for the management of NAFLD.