Redox-responsive biocompatible nanocarriers based on novel heparosan polysaccharides for intracellul

• 作 者: Lipeng Qiu Lu Ge Miaomiao Long
• 机 构: SchoolofPharmaceuticalSciences,WuxiHigherHealthVocationalTechnologySchool,WuxiThirdRenminHospital
• 出 处: 亚洲药物制剂科学(英文)
• 发表日期: 2020年1期
• 关键词: HEPAROSAN Vitamin E SUCCINATE Redox-sensitive micelles Drug delivery
• 基金项目: We are grateful for the financial support from National Natural Science Foundation of China(81503007 and 21574059),Research Project of Wuxi Health and Family Planning Commission(Q201843),Natural Scien

Heparosan is a natural precursor of heparin biosynthesis in mammals. It is stable in blood circulation but can be degraded in lysosomes, showing good biocompatibility and long circulation features. So heparosan can be designed as anticancer drug carriers