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【目的】探讨人工股骨头置换治疗高龄股骨粗隆间不稳定骨折的疗效。【方法】选择股骨粗隆间不稳定骨折高龄患者80例，随机分为两组，每组40例，观察组行人工股骨头置换手术治疗，对照组采用股骨近端锁定解剖钢板内固定治疗，两组患者术后经相同护理处理并定期随访观察，比较两组患者疗效及预后感染状况。【结果】两组手术时间、术中出血量比较无统计学差异(P >0.05)；观察组住院时间、术后下床时间及负重活动时间均显著性短于对照组，差异有统计学意义(P <0.05)；手术治疗6个月后，观察组患者髋关节功能 Harris 评分优良率为95.0%，显著性高于对照组(57.0%)(P <0.05)；观察组患者的术后感染率为20.0%，显著性低于对照组(35.0%)(P <0.05)；观察组褥疮、切口感染、尿路感染、肺部感染等各种感染并发率均显著性低于对照组(P 0.05).The average of length stay,bed time and weight-bearing activity time in the observation group were significantly shorter than the control group (P <0.05 ).Six months after surgery,the excellent treatment with Harris hip function score of the patients in the observation group was 95.0%,which was significantly higher than the 57% in the control (P <0.05);the postoperative infection rate in the observation group was 20.0%,which was significantly lower than in the control group (55.0%)(P <0.05).The bed sore,wound infections,urinary tract infections,lung infection,and other concurrent infections in the observation group were significantly lower than in the control group (P <0.05).[Conclusion]Artificial hip arthroplasty for unstable intertrochanteric frac-tures of the femur in the elderly can effectively improve clinical effects,the quality of life for elderly patients,and detect infections in a relatively reliable manner.It is worthy of further promotion and application.