论文部分内容阅读
目的 探讨血清中抗精子抗体、抗子宫内膜抗体与反复自发性流产之间的关系。方法 应用ELISA方法检测了 186例自发性流产患者血清中抗精子抗体、抗子宫内膜抗体 ,并以 5 6例正常育龄妇女作为对照。结果 反复自发性流产患者血清中的阳性率分别为 2 9.0 3%和 38.71% ,而正常对照组的阳性率分别相应为 1.79%和 3.75 % (P <0 .0 1)。血清中抗精子抗体阳率随流产次数的增加而减少 (P <0 .0 5 ) ,流产时孕期 <90d者血清中抗精子抗体阳性率明显高于流产时孕期≥ 90d者 (P <0 .0 5 ) ,抗子宫内膜抗体阳性率与流产次数和流产时孕期之间无明显关系。结论 血清血清中抗精子抗体、抗子宫内膜抗体与反复自发性流产密切相关 ,是造成反复自发性流产的重要因素 ,尤其在孕期的早期阶段检测血清中抗精子抗体、抗子宫内膜抗体更为重要。
Objective To investigate the relationship between serum anti-sperm antibodies, anti-endometrial antibodies and recurrent spontaneous abortion. Methods Serum anti-sperm antibodies and anti-endometrial antibodies were detected in 186 patients with spontaneous abortion by ELISA. Fifty-six healthy women of reproductive age were used as controls. Results The positive rates of sera in patients with recurrent spontaneous abortion were respectively 2 9.0 3% and 38.71%, while those in the normal control group were 1.79% and 3.75% (P <0.01) respectively. Serum anti-sperm antibody positive rate decreased with the increase of miscarriage times (P <0.05). The positive rate of antisperm antibody in sera during 90 days of abortion was significantly higher than that of miscarriage at 90 days (P <0. 0 5), anti-endometrial antibody positive rate and the number of abortion and pregnancy during abortion no significant relationship. Conclusion Serum anti-sperm antibodies, anti-endometrial antibodies and recurrent spontaneous abortion are closely related, causing repeated spontaneous abortion, an important factor, especially in the early stages of pregnancy serum anti-sperm antibodies, anti-endometrial antibodies more Important.