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Graves甲亢系一种自身免疫性疾病。本文观察Graves甲亢患者治疗前后抗双链DNA抗体(抗dsDNA抗体)抗单链DNA抗体(抗ss-DNA抗体)的变化,同时检测抗甲状腺球蛋白抗体(TGA),抗甲状腺微粒体抗体(TNA);以及总甲状腺激素(TT_3,TT_4)游离甲状腺激素(FT_3、FT_4),以探讨Graves甲亢的发病机理,自然转归与自身抗体的关系。 1 临床资料与方法 1.1 临床资料 Graves甲亢诊断标准:有甲亢的临床症状和体征(典型高代谢症群及/或交感神经兴奋症群和/或不同程度的甲状腺肿大,突眼),血清TT_3、TT_4/FT_3、FT_4升高,部分病人行甲状腺吸Ⅰ
Graves hyperthyroidism is an autoimmune disease. The aim of this study was to investigate the changes of anti-dsDNA antibody (anti-ssDNA antibody) in patients with Graves hyperthyroidism before and after treatment, and to detect the anti-thyroglobulin antibody (TGA), anti-thyroid microsomal antibody ) And total thyroid hormone (TT_3, TT_4) free thyroid hormones (FT_3, FT_4) to explore the pathogenesis of Graves hyperthyroidism, natural outcome and the relationship between autoantibodies. 1 clinical data and methods 1.1 clinical data Graves hyperthyroidism diagnostic criteria: hyperthyroidism clinical symptoms and signs (typical high metabolic syndrome and / or sympathetic excitability group and / or varying degrees of goiter, exophthalmos), serum TT_3 , TT_4 / FT_3, FT_4 increased, some patients underwent thyroid suction Ⅰ