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胃食管返流时可导致食管炎症、运动障碍,甚至发生癌瘤。作者对42例有胃食管返流的患者,利用胃镜在X 线监视下,取食管下端组织活检,其中Ⅰ度返流20例,Ⅱ度返流22例。病理组织学研究结果,70%患者的食管粘膜、粘膜下和部分肌层有炎症细胞浸润。但Ⅲ度返流者的炎症变化明显,范围广泛,50%患者的炎症已侵入肌层,部分患者的食管壁纤维组织形成和纤维化。一度患者炎症反应大多局限于粘膜下,发生纤维化者仅只一例。二组中均发现胃粘膜长入食管,这导致食管粘膜按胃粘膜型式重建,这一现象Ⅲ度返流中有半数(同时还见有上皮化生),而Ⅰ度返流者只15%患者出现重
Gastroesophageal reflux can cause esophageal inflammation, movement disorders, and even cancer. The authors of 42 cases of patients with gastroesophageal reflux, using endoscopy in the X-ray monitoring, take the lower esophageal tissue biopsy, of which 1 degree of reflux in 20 cases, II degree of reflux in 22 cases. As a result of the histopathological study, 70% of patients had inflammatory cell infiltration in the esophageal mucosa, submucosa, and part of the muscular layer. However, the degree of inflammatory changes in patients with grade III regurgitation was significant, with a wide range. In 50% of patients, inflammation had invaded the muscular layer, and in some patients, fibrous tissue formation and fibrosis of the esophageal wall. Once the patient’s inflammatory response was mostly confined to the submucosa, only one case of fibrosis occurred. In the second group, gastric mucosa was found to enter the esophagus, which led to remodeling of the esophageal mucosa according to the type of gastric mucosa. This phenomenon was observed in half of the III degree reflux (at the same time, there was epithelial metaplasia), while only 15% of the I degree reflux was found. The patient appeared heavy