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在发展中国家,麻疹是引起急性下呼吸道感染(ALRI)的主要原因。虽然,麻疹减毒活疫苗是目前最有效的疫苗之一,但是在许多地区,麻疹仍未得到控制。主要原因是疫苗覆盖率不高。另外,在某些地区,大部分病例见于接种年龄以下的婴儿。最近的研究提示,Edmonston-Zagreb麻疹疫苗对幼婴有较高的免疫原性,所以,通过提高麻疹疫苗覆盖率相对幼儿使用特定的疫苗株可预防大量ALRI。
In developing countries, measles is the main cause of acute lower respiratory tract infection (ALRI). Although attenuated live attenuated measles vaccine is one of the most effective vaccines to date, measles remains unmanaged in many areas. The main reason is the vaccine coverage is not high. In addition, in some areas, the majority of cases occur in infants under the age of vaccination. Recent research suggests that the Edmonston-Zagreb measles vaccine is highly immunogenic for young infants and therefore prevents large numbers of ALRIs by increasing measles vaccine coverage relative to the use of specific vaccine strains in young children.