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从1940年开始百日咳全细胞菌苗在美国已作为常规应用,用多种方法评估其效果达70%~91%。80年代开始使用的百日咳无细胞组分菌苗,它的反应性要比百日咳全细胞菌苗低。然而,一个悬而未决的问题是它们是否比百日咳全细胞菌苗更为有效?
Since 1940, B. pertussis whole-cell vaccine has been used routinely in the United States. Its efficacy has been assessed in 70% to 91% by various methods. Pertussis-free cell-based vaccine that began in the 1980s is less responsive than whole-cell B. pertussis vaccine. However, one of the pending questions is whether they are more effective than B. pertussis whole-cell vaccine.