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目的分析正常及妊娠高血压疾病胎盘组织神经内分泌激素之间关系的相关性;为防止妊高症的发生提供理论依据。方法选取180例妊娠高血压疾病患者作为观察对象,并选择同期正常妊娠的患者60例,作为对照。应用免疫组织化学(免疫组化)链霉素抗生物素-过氧化物酶法,观察两组患者胎盘组织中相关神经内分泌激素水平的变化(孕早,中,晚期),以及观察不同程度妊娠高血压疾病患者其胎盘组织中相关神经内分泌激素水平的值。结果正常组孕妇在妊娠早期胎盘组织中去甲肾上腺素水平较高,但随着妊娠进展,水平逐渐减低,而妊高征患者远高于正常组,两组相比,差异具有统计学意义,(P<0.05)。且随着患者病情的加重,其胎盘组织中去甲肾上腺素水平有显著增加的趋势。结论妊娠期高血压病患者其胎盘组织去甲肾上腺素水平明显高于正常的孕妇,且随着病情的增加有显著增加的趋势。
Objective To analyze the correlation between the neuroendocrine hormones of placenta in normal and gestational hypertensive disorders and to provide a theoretical basis for preventing the occurrence of pregnancy induced hypertension. Methods 180 patients with pregnancy-induced hypertension were selected as observation subjects and 60 normal pregnant women were selected as controls. Immunohistochemical (immunohistochemical) streptavidin-peroxidase method was used to observe the changes of the relevant neuroendocrine hormones in the placenta of the two groups (early pregnancy, middle and late pregnancy) and to observe the changes of pregnancy The value of the relevant neuroendocrine hormone levels in placental tissue of hypertensive patients. Results The level of norepinephrine in the placental tissue of the normal pregnant women was higher in the first trimester of pregnancy, but gradually decreased with the progress of pregnancy, while the patients with PIH were much higher than the normal group. The differences were statistically significant, (P <0.05). And with the aggravation of the patient’s condition, the level of norepinephrine in placental tissue has a significant increase trend. Conclusion The level of norepinephrine in placental tissue of patients with gestational hypertension is significantly higher than that of normal pregnant women, and with the increase of the disease, there is a significant increase trend.