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阻塞大脑中动脉２ ｈ，再灌流０．５～４８ ｈ 制成脑缺血模型，用免疫组织化学技术观察了脑缺血后白细胞共同抗原在脑组织的表达。结果表明：白细胞共同抗原阳性的小胶质细胞或巨噬细胞呈圆形，未见分支型小胶质细胞，阳性的小胶质细胞于再灌流３ ｈ 开始出现，再灌流１２ ｈ 数量显著增多，并且胞质、胞核均为强阳性；阳性的小胶质细胞分布于纹状体、下丘脑、杏仁核处及皮质与外囊相连处，完全坏死区无阳性小胶质细胞；此外，同侧微血管强表达白细胞共同抗原；同侧大脑皮质Ⅳ、Ⅴ、Ⅵ层锥体细胞、丘脑、海马形态正常的神经元亦强表达白细胞共同抗原，但核固缩的神经元白细胞共同抗原则呈阴性。本实验推测白细胞共同抗原可能有保护神经元的作用，并可能是神经元与小胶质细胞之间的信息传递分子。
Cerebral ischemia was occluded 2 h after occlusion of the middle cerebral artery and 0.5-48 h after reperfusion. The expression of leukocyte common antigen in brain tissue was observed by immunohistochemistry. The results showed that microglial cells or macrophages positive for leukocyte common antigen were round and no branched microglia were found. Positive microglial cells started to appear at 3 h after reperfusion, and the number of microglial cells or macrophages was significantly increased 12 h after reperfusion , And the cytoplasm and nucleus were all strongly positive. The positive microglial cells distributed in the striatum, hypothalamus, amygdala and cortex connected with the outer capsule, and there was no positive microglial cells in the necrotic area. In addition, Ipsilateral microvessels strongly expressed white blood cell common antigen; ipsilateral cerebral cortex neurons in normal, hippocampal, hippocampal pyramidal cells, thalamus, hippocampus also strongly expressed leukocyte common antigen, but the nucleus contractile neurons leukocyte common antigen was negative. The experiment speculated that the common white blood cell antigen may have the role of neurons, neurons and microglia may be the transmission of information between molecules.