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损害内质网功能的应激,导致了未折叠蛋白或错误折叠蛋白的积累。内质网应激引发了身体的许多应激反应,包括未折叠蛋白反应(UPR)。越来越多的证据显示内质网应激参与了神经退行性疾病(阿尔茨海默病、帕金森病和脑缺血性疾病)、癌症、肥胖及糖尿病。本文对哺乳动物在病理条件下内质网应激的重要性,以及对内质网应激为靶目标的治疗潜力加以讨论。
Stress that impairs endoplasmic reticulum function leads to the accumulation of unfolded proteins or misfolded proteins. Endoplasmic reticulum stress initiates many of the body’s stress responses, including unfolded protein responses (UPRs). There is growing evidence that endoplasmic reticulum stress is involved in neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease and cerebral ischemic disease), cancer, obesity and diabetes. This article discusses the importance of mammalian endoplasmic reticulum stress under pathological conditions and the therapeutic potential of endoplasmic reticulum stress as a target.