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目的了解海盐县某医院大肠埃希菌的耐药性,为临床治疗和医院感染控制提供依据。方法对2014—2016年海盐县某医院分离的2 355株大肠埃希菌采用VITEK-32型全自动细菌分析系统进行鉴定和药敏试验,并对结果进行分析。结果 2 355株大肠埃希菌主要来自分泌物标本,以普外科检出率最高。其中超广谱β-内酰胺酶(ESBLs)阳性973株,占41.32%,检出碳青霉烯药物耐药6株,大肠埃希菌对头孢唑啉、头孢哌酮/舒巴坦等耐药率呈逐年上升(P<0.05),而对庆大霉素、妥布霉素、复方新诺明等呈逐年下降趋势(P<0.05)。结论产ESBLs大肠埃希菌检出率高,碳青霉烯类药物依然是最有效的抗菌治疗药物。
Objective To understand the drug resistance of Escherichia coli in a hospital in Haiyan county and provide the basis for clinical treatment and hospital infection control. Methods A total of 2 355 isolates of Escherichia coli isolated from a hospital in Haiyan from 2014 to 2016 were identified and susceptible to antibiotics by VITEK-32 automatic bacterial analysis system. The results were analyzed. Results 2 355 strains of Escherichia coli mainly from secretions specimens, the highest detection rate in general surgery. Among them, 973 strains of ESBLs were positive, accounting for 41.32%. 6 strains were resistant to carbapenem and Escherichia coli were resistant to cefazolin and cefoperazone / sulbactam The rate of drug increased year by year (P <0.05), while the gentamicin, tobramycin and cotrimoxazole showed a decreasing trend year by year (P <0.05). Conclusion The detection rate of ESBLs-producing Escherichia coli is high, carbapenem remains the most effective antibacterial therapy.