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目的探讨妊娠期肝内胆汁於积症(ICP)对母儿的影响、监护及处理。方法以32例接受ICP治疗并且住院分娩的患者为研究对象(治疗组),并选择同期未经治疗而直接生产的住院ICP患者为对照组,进行回顾性分析。结果 32例患者经治疗后瘙痒明显缓解,血清胆汁酸、肝功能相关指标明显下降。治疗组羊水污染率、早产率、新生儿窒息率及产后出血率均低于对照组,差异有统计学意义,剖宫产率、围产儿死亡率比较差异无统计学意义。结论适当的医疗干预和有效的胎儿健康评估对改善ICP患者围产期结局意义重大。
Objective To investigate the influence, monitoring and treatment of intrahepatic cholestasis of pregnancy (ICP) on pregnant women and infants during pregnancy. Methods Thirty-two patients undergoing ICP and hospital delivery were enrolled in the study (treatment group). In-hospital ICP patients directly produced without treatment were selected as the control group for retrospective analysis. Results 32 patients were relieved of itching after treatment, serum bile acid, liver function related indicators decreased significantly. Amniotic fluid pollution rate, premature birth rate, neonatal asphyxia rate and postpartum hemorrhage rate in the treatment group were lower than those in the control group, the difference was statistically significant, cesarean section rate, perinatal mortality rate was no significant difference. Conclusion Appropriate medical interventions and effective assessment of fetal health are important for improving perinatal outcomes in ICP patients.