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子痫前期是妊娠期特有疾病,以高血压和蛋白尿等为临床特征,影响母亲和新生儿的患病率和死亡率。尽管病因至今不明,但多数学者认为其发病与胎盘因子进入母体的血循环引起血管内皮的损伤有关。近年来发现,抗血管生成因子如内皮因子、可溶性血管内皮生长因子受体1(sFlt-1)以及胎盘生长因子都与子痫前期的发生有关。对sFlt-1分子结构及作用、调节因素、相关信号转导途径及其在子痫前期发病机制中的研究结果作一综述。
Pre-eclampsia is a specific disease during pregnancy, with hypertension and proteinuria as the clinical features, affecting the morbidity and mortality of mothers and newborns. Although the etiology is still unknown, most scholars believe that the pathogenesis of placental factor into the maternal blood circulation caused by vascular endothelial damage. In recent years, anti-angiogenic factors such as endothelium, soluble vascular endothelial growth factor receptor 1 (sFlt-1), and placental growth factor have been found to be associated with the development of preeclampsia. This review summarizes the molecular structure and function of sFlt-1, regulatory factors, relevant signal transduction pathways and their roles in the pathogenesis of preeclampsia.