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冠状动脉痉挛常以变异型心绞痛作为代表性疾病,但最近认为典型心绞痛(劳累性心绞痛)及安静型心绞痛均可能与冠状动脉痉挛有关。此点有下列证据:(1)作为心肌氧消耗量指标的冠状动静脉血双份产物(double pro-duct)测定结果,在心绞痛发作和非发作期间无改变;(2)同一患者引起心绞痛的指标阈值并不一致;(3)经心房起搏单纯使心率加快而诱发心绞痛发作时其指标显著增大等。这些事实均与因固定的冠状动脉狭窄所致冠状血流量受限致使心肌氧供需失衡而引起心绞痛的这种传统的劳累性心绞痛的发生机理相矛盾。
Coronary artery spasm often variant angina as a representative disease, but recently that the typical angina (angina pectoris) and angina pectoris may be related to coronary artery spasm. This point has the following evidence: (1) results of double pro-duct coronary angiography as an indicator of myocardial oxygen consumption, unchanged during angina pectoris and non-seizure; (2) angina pectoris Index threshold is not consistent; (3) atrial pacing simply to make the heart rate increased angina pectoris when the index was significantly increased. These facts are contradictory to the traditional mechanism of exertion angina pectoris that causes angina pectoris due to imbalance of supply and demand of myocardial oxygen due to limited coronary blood flow caused by fixed coronary stenosis.