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丙磺舒是苯甲酸的一种脂溶性衍生物,主要用于抑制上皮组织(比如肾小管)对其他有机酸的转运.丙磺舒的半衰期接近9小时,所以每天只需给药2～3次.它通常和普鲁卡因青霉素G或氨苄青霉素联用治疗淋病以提高和延长这些药物的血清浓度.口服头孢菌素比如头孢氨苄和头孢拉定半衰期相对较短(大约50分钟).由于他们主要是以原药形式通过肾脏排出(肾小球过滤和肾小管分泌),因此同时服用丙磺舒可以减少这些药物的排除并从而减少他们的用药剂量.
Probenecid, a fat-soluble derivative of benzoic acid, is primarily used to inhibit the transport of other organic acids in epithelial tissues, such as the tubules. Probenecid has a half-life of nearly 9 hours, so administration of 2 to 3 It is usually given in combination with procaine penicillin G or ampicillin for the treatment of gonorrhea to increase and prolong the serum concentration of these drugs.Oral cephalosporins such as cephalexin and cephradine have a relatively short half-life (about 50 minutes) due to their predominance Is excreted through the kidneys (glomerular filtration and tubular secretion) in the form of a prodrug, so administration of probenecid at the same time can reduce the elimination of these drugs and thereby reduce their dosing.