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目的 探讨老年糖尿病患者止、凝血变化及其临床意义。 方法 分别检测老年糖尿病组和对照组止、凝血指标 ,包括血浆凝血酶 抗凝血酶Ⅲ复合物 (TAT)、血管性血友病因子抗原 (vWF :Ag)、蛋白C抗原 (PC :Ag)、蛋白S抗原 (PS :Ag)、P 选择素 (P selectin)、组织纤溶酶原激活物活性 (tPA :A)、纤溶酶原激活剂抑制剂 (PAI 1:A)及D 二聚体 (D D)。 结果 与对照组相比 ,老年糖尿病组的PC :Ag、PS :Ag和D D均显著增高 (P <0 0 5 ) ,vWF :Ag、TAT、t PA :A、PAI :A、P selectin增高更为明显 (P <0 0 1)。 结论 老年糖尿病患者止、凝血功能异常主要表现为血管内皮损伤、凝血系统激活、纤溶活性降低和血小板的激活 ,这些止凝血的变化与糖尿病的血管并发症密切相关
Objective To investigate the changes of clotting and clotting in elderly patients with diabetes mellitus and its clinical significance. Methods The indexes of coagulation, including TAT, vWF: Ag and PC: Ag in elderly diabetic patients and controls were detected. , Protein S antigen (PS: Ag), P selectin, tissue plasminogen activator activity (tPA: A), plasminogen activator inhibitor (PAI 1: A) and D dimerization Body (DD). Results Compared with the control group, the PC: Ag, PS: Ag and DD were significantly increased in the elderly diabetic group (P <0.05), and the levels of vWF: Ag, TAT, t PA: A, PAI: A, As obvious (P <0.01). Conclusions The abnormal coagulation function of elderly patients with diabetes is mainly manifested as vascular endothelial injury, activation of coagulation system, reduction of fibrinolytic activity and activation of platelets, which are closely related to the vascular complications of diabetes