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家兔以乌拉坦麻醉肝素抗凝,行颈总及股动脉插管术,经GOULD P23 1D换能器与San ei生理多导仪相联,分别测左室内压、±dp/dt及血压。动物随机分为4组:1组(n=10)于实验前半小时耳缘静脉注入生理盐水(4ml/kg),行腹部手术分离腹腔动脉后,描记正常状态(0时)血压等曲线,立即夹闭该动脉并于30、60(停止夹闭即刻)、90、120及150分时各记录相应血液动力学指标,并记录动物死亡时间;2组(n=8)于实验前小时耳缘静脉注射0.5％阿司匹林溶液4ml/kg(20mg/kg,PH=7.4)其余方法同1组;3组
Rabbits were anesthetized with urapidil heparin anticoagulation, neck and femoral artery catheterization, GOULD P23 1D transducer and San ei physiological multi-guide instrument associated, measured left ventricular pressure, ± dp / dt and blood pressure. The animals were randomly divided into 4 groups: Group 1 (n = 10). Normal saline (4ml / kg) was injected into the ear vein half an hour before the experiment. Abdominal surgery was performed to separate the celiac artery. The artery was occluded and the respective hemodynamic parameters were recorded at 30 and 60 (immediately after clamping was stopped). The corresponding hemodynamic parameters were recorded at 90, 120 and 150 minutes, and the animal death time was recorded. Two groups (n = 8) Intravenous injection of 0.5% aspirin solution 4ml / kg (20mg / kg, PH = 7.4) the rest of the same group 1; 3