直肠癌患者血清白介素-8、TNA-α及T细胞亚群的临床研究

• 机 构: Department of General Surgery,the 81st Hospital of PLA,Nanjing 210002,China;Department of Pharmacy,t
• 出 处: 中德临床肿瘤学杂志（英文版）
• 发表日期: 2011年2期
• 关键词: rectal cancer T-cell subgroup interleukin-8 tumor necrosis factor

Objective:The aim of our study was to investigate the immune status of patients with rectal cancer and its relationship with clinicopathological features.Methods:The serum levels of interleukin-8(IL-8),tumor necrosis factor(TNF-a)and T-cell subgroup contents were measured using a double-antibody sandwich assay of ELISA in 43 patients with rectal cancer,and compared with the normal health adults.Results:In patients with rectal cancer,the serum levels of CD4,CD4/CD8of T-cell subgroup in peripheral blood were significantly lower than the control group(P<0.01),which gradually decreased with increase of Dukes stage;but the levels of CD8,IL-8 and TNF-a were higher than the control group,which gradually increased with increase of Dukes stage.Conclusion:The immunocompromice exists in patients with rectal cancer,there is a correlation between the contents of T-cell subgroup,IL-8 and TNF-a in serum and the Dukes stage of rectal cancer.Therefore immunotherapy can be used in patients with rectal cancer.