离子液体中无膦、无铜、钯催化的Sonogashira交联反应的研究

• 作 者: 李红玲 张霞 蔺红桃 齐彦兴
• 机 构: 中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室,中国科学院研究生院,兰州大学功能有机分子化学国家重点实验室,
• 出 处: 分子催化
• 发表日期: 2009年05期
• 关键词: 交联反应 钯催化 Sonogashira 催化体 离子液体 循环使用 炔烃 液体 催化活性 碘代

研究了离子液体中无膦、无铜、钯催化剂在Sonogashira交联反应中的催化性能.系统考察了反应温度、溶剂、钯源、碱等因素的影响及底物的适用性.研究结果表明,该催化体系对各种电子效应的碘代烷和末端炔烃的Sonogashira交联反应是十分有效的,反应在温和的条件下取得较好的收率.此外,该催化体系有很好的重复使用性,循环四次后催化活性只有略微的降低.

The catalytic performance of phosphine-free, copper-free and palladium catalysts in Sonogashira cross-linking reaction was studied.The effects of reaction temperature, solvent, palladium source and alkali and the applicability of the substrate were investigated systematically.The results show that the non- The catalytic system is very effective for Sonogashira cross-linking reaction of various electronic effects of alkyl iodides and terminal alkynes, and the reaction yields good yields under mild conditions. In addition, the catalytic system is well reused Sex, after four cycles of catalytic activity only slightly reduced.